Multidisciplinary Acute Care Research Organization (MACRO)

The Multidisciplinary Acute Care Research Organization (MACRO) provides support services to principal investigators seeking to maximize the productivity and efficiency of acute care research, from the pre-hospital setting to the ICU and inpatient wards. MACRO offers a wide range of services, including 24/7 screening and enrollment into clinical trials and assistance in the conduct of prospective, observational, patient-oriented acute care research. Our mission is to advance medicine and science, through excellence in execution of screening and enrollment day-and-night, local and national coordination, and stakeholder education of multidisciplinary clinical research. Our vision is to be the national role model for academic multidisciplinary clinical research organizations.

MACRO Services

  • Coordination of multicenter studies
  • 24/7 subject screening, informed consent and enrollment
  • Protocol review and execution
  • Budgeting
  • IRB submission and coordination
  • Regulatory support and coordination
  • Clinical research coaching for new investigators and trainees

MACRO supports studies of any size, ranging from large multicenter trials to small, single-center, short-term projects. Specific areas of focus include sepsis, ARDS, and trauma; we also facilitate non-acute care studies in neurosurgery, nephrology, bioengineering, and other areas. 

Research Associate Internship Program

MACRO maintains a paid research associate program for University of Pittsburgh undergraduate students with a strong interest in healthcare and research careers. The Research Associate Internship Program page has more details and information on how to apply.

Leadership & Oversight

MACRO functions as a partnership between the University of Pittsburgh Departments of Critical Care Medicine, Surgery, Emergency Medicine, and Medicine; and is led by an interdepartmental Executive Committee that includes:

  • David Huang, MD, MPH, Director
  • Jason Sperry, MD, MPH, Co-Director
  • Alan Abraham, Director
  • Clifton W. Callaway, MD, PhD, Co-Director
  • Bryan McVerry, MD, Co-Director


Alan Abraham: