Robert S.B. Clark, MD

  • Vice Chair of Pediatric Critical Care
  • Professor of Critical Care Medicine and Pediatrics
  • Medical Director, UPMC Children’s Hospital of Pittsburgh Brain Care Institute
  • Associate Director, Safar Center for Resuscitation Research
  • UPMC Endowed Chair, Pediatric Critical Care Medicine

    Education & Training

  • BS, Engineering and Biology, Utah State University, 1985
  • MD, Medical College of Wisconsin, 1989
  • Residency, Pediatrics, University of Utah, 1992
  • Fellowship, Critical Care Medicine, UPMC Children’s Hospital of Pittsburgh, 1995
Charter member, National Institute of Neurological Disorders and Stroke, Clinical Neuroscience and Disease Study Section, 2001-2004
Regular member, National Institute of Neurological Disorders and Stroke, Developmental Brain Disorders Study Section, 2005-2009
Vice President National Neurotrauma Society, 2011
Pittsburgh Magazine's list of the “Best Doctors in Pittsburgh,” 2012-2018
Representative Publications

Du L, Bayir H, Lai Y, Zhang X, Kochanek PM, Watkins SC, Graham SH, Clark RS. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. Journal of Biological Chemistry. 2004 Sep 10;279(37):38563-70.

Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT, Kagan VE, Clark RS . Starving neurons show sex difference in autophagy. Journal of Biological Chemistry. 2009 Jan 23;284(4):2383-96.

Hagos FT, Empey PE, Wang P, Ma X, Poloyac SM, Bayir H, Kochanek PM, Bell MJ, Clark RS. Exploratory application of neuropharmacometabolomics in severe childhood traumatic brain injury. Critical care medicine. 2018 Sep 1;46(9):1471-9.

Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RS. Synthesis and Evaluation of a Mitochondria-Targeting Poly (ADP-ribose) Polymerase-1 Inhibitor. ACS chemical biology. 2018 Sep 5;13(10):2868-79.

Research Interests
  • Refining the practice of pediatric neurocritical care
  • Integrating IT platforms for delivering high-performing and high-value critical care
  • Novel therapeutics and repurposed therapeutics for neuroprotection
  • The role of brain-blood interface transporters in brain injury