Sepsis Not ‘One-Size Fits All” CCM Study Finds

Research conducted by associate professor Chris Seymour, MD, MSc, and colleagues in the Department of Critical Care Medicine finds four distinct sepsis types. The “Sepsis ENdotyping in Emergency Care” (SENECA) Project used computer algorithms to analyze 29 clinical variables found in the electronic health records of more than 20,000 UPMC patients, who were recognized as having sepsis within six hours of hospital arrival.

The algorithm clustered the patients into four distinct sepsis types, described as:

Alpha: most common type (33%), patients with the fewest abnormal laboratory test results, least organ dysfunction and lowest in-hospital death rate at 2%;

Beta: older patients, comprising 27%, with the most chronic illnesses and kidney dysfunction;

Gamma: similar frequency as beta, but with elevated measures of inflammation and primarily pulmonary dysfunction;

Delta: least common (13%), but most deadly type, often with liver dysfunction and shock, and the highest in-hospital death rate at 32%. 

Read more about the SENECA Project and the results. The project was published in JAMA on May 19, 2019.