Robert S.B. Clark, MD

Professor of Critical Care Medicine and Pediatrics
Vice Chair of Pediatric Critical Care

UPMC Endowed Chair, Pediatric Critical Care Medicine

Contact Information


Administrative Contact:
Phyllis Starz

Education & Training

BS, Engineering and Biology, Utah State University, 1985
MD, Medical College of Wisconsin, 1989
Residency, Pediatrics, University of Utah, 1992
Fellowship, Critical Care Medicine, UPMC Children’s Hospital of Pittsburgh, 1995

Research, Clinical & Academic Interests

  • Refining the practice of pediatric neurocritical care
  • Integrating IT platforms for delivering high-performing and high-value critical care
  • Novel therapeutics and repurposed therapeutics for neuroprotection
  • The role of brain-blood interface transporters in brain injury

Du L, Bayir H, Lai Y, Zhang X, Kochanek PM, Watkins SC, Graham SH, Clark RS. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. Journal of Biological Chemistry. 2004 Sep 10;279(37):38563-70.

Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT, Kagan VE, Clark RS . Starving neurons show sex difference in autophagy. Journal of Biological Chemistry. 2009 Jan 23;284(4):2383-96.

Hagos FT, Empey PE, Wang P, Ma X, Poloyac SM, Bayir H, Kochanek PM, Bell MJ, Clark RS. Exploratory application of neuropharmacometabolomics in severe childhood traumatic brain injury. Critical care medicine. 2018 Sep 1;46(9):1471-9.

Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RS. Synthesis and Evaluation of a Mitochondria-Targeting Poly (ADP-ribose) Polymerase-1 Inhibitor. ACS chemical biology. 2018 Sep 5;13(10):2868-79.

Medical Director, UPMC Children’s Hospital of Pittsburgh Brain Care Institute
Associate Director, Safar Center for Resuscitation Research

Charter member, National Institute of Neurological Disorders and Stroke, Clinical Neuroscience and Disease Study Section, 2001-2004
Regular member, National Institute of Neurological Disorders and Stroke, Developmental Brain Disorders Study Section, 2005-2009
Vice President National Neurotrauma Society, 2011
Pittsburgh Magazine's list of the “Best Doctors in Pittsburgh,” 2012-2018