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Systems Medicine Program

Our Vision

The systems medicine program seeks to explore the intersection of advances quantitative methods and bedside care with the ultimate vision of leveraging mathematical, computational and engineering expertise to deliver improved personalized care to the critically ill. We also believe that such work is best accomplished by scientists that can bridge cultural differences between clinical medicine and quantitative sciences.


The systems medicine program is highly transdisciplinary and maintains a diversified portfolio of projects. Within CRISMA, the program has overlapping interests and shares resources with The Center for Critical Care Nephrology and the Health Policy & Management program. These projects are supported through federal agencies (NIGMS, NIAID, NLM, NSF, NIDDK, NHLBI) and through industry collaborations. The genesis of the systems medicine program was itself transdisciplinary through a privileged collaboration with investigators from the Departments of mathematics (Carson Chow) and surgery (Yoram Vodovotz) supported by an exploratory grant "Modeling the acute inflammatory response" back in 2002, an early contribution to the NIH Roadmap Initiative seeking the integration quantitative methods and systems approaches to improving patient care. Since, our portfolio and resources have expanded considerably with a variety of collaborations, locally, nationally and internationally.

We follow a distributed model in there is no forced overlap between projects that are distinct from each other. Teams are constituted accordingly and operate independently.

Current Projects

Modeling the acute inflammatory response

Modeling the biological response to Influenza A virus

Discovering patterns in large datasets

Streamlining healthcare delivery

Glucose control in the critically ill