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Systems Medicine Links

The Society for Complexity in Acute Illness (SCAI)

Inflammation and organ dysfunction that accompany trauma and sepsis are complex, multi-focal problems. Enormous amount of money, both public and private, have been spent on research and clinical care for this constellation of diseases. Though exciting laboratory breakthroughs derived from reductionist approaches await translation to the clinic, few therapeutic options are available today. New paradigms are needed to truly impact care for acute illness.

We formed SCAI because we believe passionately that complex systems approaches, involving modeling, simulation, systems biology, chaos theory, and network theory can augment the classical, hypothesis-driven approach that has largely failed to stem the tide of critical illness.


International Conference on Complexity in Acute Illness (ICCAI)

Critical illness is the result of the interplay of complex physiology, complex decision making and a complex environment.  ICCAI gathers outstanding mathematicians, engineers, biological scientists, clinicians and industry participants to present recent advances in filling decision making resulting in improved patient outcomes.


Center for Inflammation and Regeneration Modeling (CIRM)

To investigate the complex process of inflammation and its relationship to regenerative medicine, the McGowan Institute established the Center for Inflammation and Regeneration Modeling (CIRM).  The McGowan Institute for Regenerative Medicine was established by the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center (UPMC) to explore the vast potential of tissue engineering and other techniques for repairing damaged or diseased tissues and organs. The McGowan Institute serves as a single base of operations for the University’s leading scientists and clinical faculty members who are working to develop tissue engineering, cellular therapies, biosurgery, and artificial and biohybrid organs.


University of Pittsburgh - Affiliated Departments/Centers


Industrial Engineering

Clinical & Translational Science Institute (CTSI)

Biomedical Informatics

Center for Vaccine Research

Computational and Systems Biology

Computer Science


Infectious Diseases & Microbiology

McGowan Institute for Regenerative Medicine

Microbiology and Molecular Genetics

MIDAS National Center of Excellence - Models of Infectious Disease Agent Study