Derek C. Angus, MD, MPH, FRCP, Chair, Department of Critical Care Medicine
Dr. Angus is Chair of the Department of Critical Care Medicine of both the University of Pittsburgh School of Medicine and the UPMC Healthcare System. At the University, he holds the rank of Distinguished Professor and the Mitchell P. Fink Endowed Chair in Critical Care Medicine with secondary appointments in Medicine, Health Policy and Management, and Clinical and Translational Science and he directs the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illnesses) Center. He also co-directs the UPMC ICU Service Center, responsible for the provision of ICU services across the 20-plus hospital system.
Upon completing his undergraduate studies at the University of Glasgow School of Medicine, Glasgow, United Kingdom, Dr. Angus completed his intern and residency training at the Western Infirmary and the Southern General Hospital in Glasgow. He then traveled to the U.S. and obtained his MPH from the University of Pittsburgh Graduate School of Public Health. During this time he was a Fellow of Critical Care Medicine, a Research Fellow, and a Research Fellow in Disaster and Emergency Medicine at the University of Pittsburgh.
Dr. Angus’ research interests include clinical, epidemiologic and translational studies of sepsis, pneumonia, and multisystem organ failure and health services research of the organization and delivery of critical care services. Dr. Angus has led several large NIH-funded multicenter studies in the critically ill, the most recent of which is ProCESS (Protocolized Care for Early Septic Shock), a 40-center study focusing on how to best provide early resuscitation for septic shock. Dr. Angus has published several hundred papers, reviews and book chapters, and is currently section editor for “Caring for the Critically Ill” for JAMA. He is the recipient of numerous awards, including the Presidential Citation Award of the Society of Critical Care Medicine (1999, 2004-2006, 2008, 2011, 2013), the Master of Critical Care Medicine from the American College of Critical Care Medicine 2012), Best Doctors of America (2005-present), and the Best Doctors in Pittsburgh (2012-present), Top 10 Outstanding Clinical Research Achievements from the Clinical Research Forum (2015) and an Honorary Member of the European Society of Intensive Care Medicine (2015). Dr. Angus is a member of the Society of Critical Care Medicine, the American College of Chest Physicians, the American Thoracic Society, the Association for Health Services Research, the European Society of Intensive Care Medicine, and the American College of Critical Care Medicine.
Timothy R. Billiar, MD, Professor and Chair, Department of Surgery
Dr. Billiar trained in General Surgery at the University of Minnesota and University of Pittsburgh. This included a four year fellowship in translational research. Over the past 24 years he has been a practicing Acute Care Surgeon and Surgeon Scientist. His laboratory and research program have long-standing interest in the host response to severe trauma and surgical sepsis. In the field of trauma, The Department of Surgery has worked extensively with human systems as well as small animal models of multisystem injury. It has contributed to the understanding of the role of nitric oxide and pattern recognition receptors and damaged associated molecular patterns as regulators of the immuno-inflammatory response to injury. The Department has also carried out extensive studies on inflammatory networks and a large number of severely injured humans and have contributed to the understanding of the differences in circulating biomarkers that coincide with distinct organ dysfunction phenotypes. As part of this work it has established a mechanism to isolate blood upon arrival and at intervals after admission at our busy trauma center. The Department of Surgery is experienced at sample collection and bio banking as well as the maintenance of a robust status set. In addition, Dr. Billiar has been a highly productive physician investigator as supported by objective evidence of the H index of 124 and over 58,000 citations to my work in the biomedical literature. He was awarded the Medallion for Scientific Achievement from the American Surgical Association (its highest honor) and received the Award for Scientific Achievement from the Shock Society, and he is also President-elect of the North American Shock Society. Dr. Billiar has interacted extensively with Dr. Lederer in the past and looks forward to participating in this exciting project by providing samples and contributing human samples.
Donald M. Yealy, MD, FACEP, Chair, Department of Emergency Medicine, University of Pittsburgh/University of Pittsburgh Physicians; Senior Medical Director, Health Services Division, UPMC; Vice President, Emergency and Urgent Care Services, Physician Services, UPMC; Professor of Emergency Medicine, and Clinical and Translational Sciences, University of Pittsburgh School of Medicine
Dr. Yealy oversees the training of 48 emergency medicine residents and fellows in 5 programs, the acute care research created by one of the consistently top funded EM departments in the US, and care delivered to nearly one million acutely ill or injured patients a year at emergency departments and urgent cares in Western PA.
Dr. Yealy obtained a bachelor degree in biology at Villanova University and a medical degree at the Medical College of Pennsylvania. He then completed an emergency medicine residency and a research fellowship at the University of Pittsburgh. In his over 310 publications, he was lead or senior author on NIH-funded efforts in airway management, acute pneumonia, acute heart failure, pulmonary embolism and sepsis care. Dr. Yealy is Deputy Editor of Annals of Emergency Medicine, has edited four other textbooks and served as a referee for 20 scientific journals.
In the past decade, Dr. Yealy received the highest research recognition by both ACEP and SAEM, the highest educational award by ACEP, and the leadership award for SAEM; he is the only emergency physician to have received those 4 highest awards. He was bestowed the Ralph C. Wilde Award for excellence in care and leadership by the Allegheny County Medical Society.
Mark Gladwin, MD, Chair, Department of Medicine
Dr. Gladwin received his M.D. from the University of Miami Honors Program in Medical Education in 1991. After completing his internship and chief residency at the Oregon Health Sciences University in Portland, Ore., he joined the NIH in 1995 as a critical care fellow in the Clinical Center. After completion of a clinical fellowship in pulmonary medicine at the University of Washington in Seattle, he returned for a research fellowship at the Critical Care Medicine Department, CC, under the mentorship of James Shelhamer, Frederick Ognibene, Alan Schechter, and Richard Cannon. He later served as the Chief of the Pulmonary and Vascular Medicine Branch within the NHLBI, NIH. In August of 2008, Dr. Gladwin became Chief of the Pulmonary, Allergy and Critical Care Medicine Division at the University of Pittsburgh School of Medicine and the Director of the newly formed Hemostasis and Vascular Biology Research Institute (now the Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute). In March 2015, Dr. Gladwin was appointed Chairman of the Department of Medicine in the University of Pittsburgh School of Medicine.