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RESTORE - Randomized evaluation of sedation titration for respiratory failure

Director: R. Scott Watson, MD, MPH

PI: Martha A.Q. Curley, RN, PhD, FAAN, University of Pennsylvania School of Nursing

Data Coordinating Center PI: David Wypij, Ph.D., Children's Hospital Boston

Funding: NHLBI

The Randomized Evaluation of Sedation Titration fOr Respiratory failurE (RESTORE) is an NIH sponsored study of 2,900 mechanically ventilated children at 31 pediatric intensive care units across the United States. The purpose of the study is to evaluate the effects of a sedation protocol in children with acute respiratory failure on the duration of mechanical ventilation, hospital and post-discharge resource use, and the post-discharge quality of life and emotional health of ventilated children.

Lead by Dr. Watson, the CRISMA Center team is coordinating and conducting the long-term follow-up for subjects enrolled in the RESTORE Study. Approximately 1,0000 subjects enrolled in the RESTORE Study are being randomly selected to be contacted by the CRISMA Center 6 months after discharge from the PICU. The follow-up protocol is comprised of a telephone interview as well as a mailed or internet-based standardized instruments measuring quality of life and emotional health. The goals of RESTORE Follow-up are to evaluate the sedation intervention’s effects on post-discharge resource use, costs, and patient-centered outcomes.

 Contact RESTORE Follow-up


Toll-free: 1-888-238-0365 

*The RESTORE trial is registered with under the number NCT00814099