PI: Robert Clark, MD
Funding: National Institute of Neurologic Diseases and Stroke P01NS030318
Energy failure contributes importantly to cell death after traumatic brain injury. Recent studies suggest that a key participant in cellular energy failure is the abundant enzyme poly(ADP-ribose) polymerase (PARP) which is present in all cells. We aim to establish the role of PARP in traumatic brain injury. Pharmacologic inhibition of PARP may prove to be a powerful and clinically relevant means of reducing energy failure and cell death, and thereby improving neurologic outcome after traumatic brain injury.