Funded by the Surgical Infection Society, this project will provide essential preliminary data for the design of a randomized trial of prehospital sepsis treatment. We will to test “very early” goal directed resuscitation in a novel murine model of septic shock, using physiologic and behavioral changes measured with embedded monitors to identify the point of acute deterioration (e.g. 9-1-1 call). This is collaborative work with the University of Pittsburgh Department of Surgery.
Lewis A, Yuan D, Zhang X, Angus DC, Rosengart M, Seymour CW. Use of biotelemetry to define physiology-based deterioration thresholds in a murine cecal ligation and puncture model of sepsis, Crit Care Med. 2016 Feb 9 [Epub ahead of print]. PMID: 26862708