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Gender-Specific Treatment of Pediatric Cardiac Arrest

PI: Robert Clark, MD

Funding: National Institute of Child Health and Human Development R01HD045968 (Project period: 5/1/05 to 2/28/11)

Quality survival after brain injury is the greatest unmet need in critically ill children. An important factor in this unmet need, is morbidity and mortality from hypoxic-ischemic encephalopathy. Hypoxic-ischemic encephalopathy is pathophysiologically complex and heterogeneous, and remains incurable. The impact of continuation of this research program would be discovery of therapies that prevent and ultimately reverse hypoxic-ischemic encephalopathy in children.