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EPR-CAT: Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma

PI: Samuel Tisherman, MD

Co-Investigator: Patrick Kochanek, MD

Funding: U.S. Army

Cardiopulmonary resuscitation (CPR) can save victims of normovolemic cardiac arrest (CA), e.g., ventricular fibrillation.  During exsanguination CA from trauma, however, CPR, even with an emergency department (ED) thoracotomy and open chest CPR, doesn’t work. Emergency Preservation and Resuscitation (EPR) was developed to rapidly preserve the organism during ischemia, using hypothermia, drugs, and fluids, to “buy time” for transport and resuscitative surgery.  The purpose of this study is to test the feasibility of rapidly inducing profound hypothermia (< 10oC) with an aortic flush in trauma victims that have suffered CA and failed standard resuscitative efforts to enable resuscitative surgery and delayed resuscitation with cardiopulmonary bypass. The primary outcome variable will be survival to hospital discharge with minimal neurologic dysfunction.