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Bacterial Pneumonia and Neutrophil Recruitment during Acute Renal Failure


PI: Kai Singbartl, MD

Co-Investigators: John A Kellum, MD; Mitchell P Fink, MD; John R Hotchkiss, MD

Funding: NIH K08GM081459

Sepsis remains a leading cause of mortality in the United States. It is most frequently caused by pneumonia. New onset of acute kidney injury (AKI) during early sepsis greatly increases the morbidity and mortality of sepsis. Experimental data suggest that the devastating effects of AKI in the critical care setting involve modulation of the inflammatory response. However, the exact mechanism by which ARF affects remote organ (dys-) function during bacterial infections is largely unknown. The proposed studies aim at unraveling the effect of AKI on neutrophil function and bacterial pneumonia, using various in vitro and in vivo techniques as well as clinical research