Associate Professor, Pediatrics and Critical Care Medicine
Medical Director, Pediatric Intensive Care Unit, Children’s Hospital of Pittsburgh
Dr. Aneja’s research entails understanding the regulation of the heat shock response by a nuclear protein called Poly (ADP) ribose polymerase (PARP). Recent studies indicate that PARP-1 also acts as a co-transcription factor for many cellular proteins. Dr. Aneja is also examining its impact on lipopolysaccharide mediated High Mobility Group Box 1 (HMGB-1) protein secretion. HMGB-1 is a DNA binding protein with cytokine like properties and is thought to be a key mediator of sepsis. Dr. Aneja’s clinical research interests include the use of plasma exchange in multi-organ failure associated with sepsis. Recent publications are in the Journal of Immunology and Journal of Leukocyte Biology.