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Rajesh Aneja, MD

Associate Professor, Pediatrics and Critical Care Medicine
Medical Director, Pediatric Intensive Care Unit, Children’s Hospital of Pittsburgh

Dr. Aneja’s research entails understanding the regulation of the heat shock response by a nuclear protein called Poly (ADP) ribose polymerase (PARP). Recent studies indicate that PARP-1 also acts as a co-transcription factor for many cellular proteins. Dr. Aneja is also examining its impact on lipopolysaccharide mediated High Mobility Group Box 1 (HMGB-1) protein secretion.  HMGB-1 is a DNA binding protein with cytokine like properties and is thought to be a key mediator of sepsis. Dr. Aneja’s clinical research interests include the use of plasma exchange in multi-organ failure associated with sepsis.  Recent publications are in the Journal of Immunology and Journal of Leukocyte Biology.

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