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Multi-center Pitt-led Pediatric Traumatic Brain Injury Trial Completes Enrollment

Thu, 10/06/2016

The Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial, led by Michael Bell, MD, Professor in the Department of Critical Care Medicine, and Stephen Wisniewski, PhD, Professor in the Department of Epidemiology in the Graduate School of Public Health, has completed enrollment of its 1000 subjects.

Funded by the National Institute of Neurological Disorders and Stroke and conceived and implemented by the Department of Critical Care Medicine, the Safar Center for Resuscitation Research, and the Department of Epidemiology, the ADAPT Trial is comparing the effectiveness of intracranial hypertension therapies, secondary insults, and metabolic support. In addition to these primary goals, a number of secondary analyses are planned, including the ability of various characteristics to predict mortality and/or outcomes, the effect of multi-system trauma on mortality from severe TBI, and differences in the epidemiology of severe TBI across countries in the developed world. This cohort – generated from 50 clinical sites in 8 countries – is the largest studied to date.

Michael Bell, MD Stephen Wisniewski, PhD

At the completion of the follow-up and analysis phases of the study, several new Level II guidelines are anticipated to improve clinical care and enhance clinical research protocols for future trials. “Drs. Bell and Wisniewski have led a pioneering study that has assembled a database of unprecedented magnitude in our field,” said Patrick Kochanek, MD, MCCM, Director of the Safar Center and a co-investigator on this project. “We hope this database will yield important findings that will improve the care and outcomes of infants and children with severe TBI world-wide.”