Patrick Kochanek, MD, Director of the Safar Center for Resuscitation Research, and his co-investigator, Raj Aneja, MD, have been awarded a three-year contract with the Department of Defense (DoD) to study novel pre-clinical strategies to prevent brain edema in traumatic brain injury and polytrauma. They will be pursuing TLR4-related pathways. Their work is a collaborative study between the Safar Center and the Walter Reed Army Institute of Research.
Professor Kochanek’s 30-year research career has focused on experimental and clinical traumatic brain injury (TBI) and cardopulmoary arrest (CA) for the pediatric and adult arenas. He pioneered the groundbreaking concept of multi-center, multi-model, pre-clinical therapeutic and biomarker screening in TBI through his involvement as principal investigator of Operation Brain Trauma Therapy (OBTT), a partnership between civilian and DoD investigators. OBTT produced the first pre-clinical multicenter consortium evaluating novel therapies and biomarkers for TBI across multiple models. Dr. Kochanek is Director of the Safar Center for Resuscitation Research, which is one of three research centers within the Department of Critical Care Medicine. Researchers at the Safar Center identify and promote ever-improving methods of preventing premature death and reducing associated disability from trauma and cardiac arrest in people with “hearts and brains too good to die.”
Dr. Aneja, an Associate Professor of Pediatrics and Critical Care Medicine, studies the regulation of the heat shock response by a nuclear protein called Poly (ADP) ribose polymerase (PARP). His clinical research interests include the use of plasma exchange in multi-organ failure associated with sepsis. He is the Medical Director of the Pediatric Intensive Care Unit at Children’s Hospital of Pittsburgh of UPMC.