Eric B. Milbrandt, MD, MPH, FCCP, FACP is an Assistant Professor in the Department of Critical Care Medicine at the University of Pittsburgh School of Medicine. During his CCM Grand Rounds lecture “Rehabilitation Strategies to Enhance Muscle Precursor Cell Function in ICU-Acquired Weakness,” he reviewed the data supporting early application of muscle building technologies, including electrical muscle stimulation and cycle ergometry on maintenance of muscle mass and on clinical indices of strength in critically ill patients. He discussed evidence from animal studies describing the impact of bed rest and electrical muscle stimulation on cellular and histological changes in muscle and muscle precursor cells. Dr. Milbrandt proposed an ambitious interventional study of the impact of electrical stimulation and cycle ergometry on the problem of ICU acquired muscle weakness. A team of investigators would study histological changes in the muscles of critically ill patients, indicators of the patient's muscle cell recovery, like muscle precursor cell growth kinetics, as well as clinical indicators of patient strength.