Michael Matthay, MD, is Professor of Medicine and Anesthesiology and Director of the Critical Care Medicine Fellowship in the Department of Medicine at the University of California, San Francisco. He was invited this year to deliver the Grenvik lectures. Dr. Matthay has published approximately 500 scientific papers plus over 100 books and book chapters. He has also mentored 50 research fellows at the famous Cardiovascular Research Intsitute (CVRI). He started with an exciting research conference on November 14, entitled "Mesenchymal Stem Cells for the Treatment of Acute Lung Injury." As the leader of the group at CVRI, he reported on findings in two areas. The first was a study in mice demonstrating improved survival, increased production of antiinflammatory cytokines and reduced number of E. Coli in lungs of these animals after instillation into the trachea of E. Coli endotoxin and subsequent infusion of mesenchymal stem cells. The second study involved human lung preparations demonstrating how endotoxin decreased alveolar fluid clearance to zero but this was restored after administration of mesenchymal stem cells. With these studies concluded, Dr. Matthay announced that UCSF together with the University of Pittsburgh is ready to submit an NIH grant application for a human Phase I trial study regarding patient safety in using MSC. The PI at Pitt will be Dr. Luis Ortiz, Director of the Division of Occupational Medicine. Several other Pitt School of Medicine faculty members will be involved, including a selected member of the Department of Critical Care Medicine. Dr. Matthay's second lecture on November 15 was an outstanding review of current knowledge of ARDS and treatment of acute lung injury. His two presentations stirred up numerous questions in the subsequent discussion. Dr. Michael Pinsky introduced Dr. Matthay before his research conference and Dr. Derek Angus concluded the second day's presentation by congratulating Dr. Matthay for his successful research and thanked him for a most appreciated visit to our department.