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Journal Club - Adult

The Department convenes a multidisciplinary evidence-based medicine journal club several times a month. Journal Club is a mandatory component of CCM training at the University of Pittsburgh. The purpose of journal club is to provide critical appraisals of articles that impact the clinical practice of critical care and to foster the development of skills necessary for the practice of evidence-based medicine. With the guidance of a faculty mentor, fellows in the University of Pittsburgh Critical Care Training Program lead the discussion of an article, which is chosen based on the following criteria: the article must have been published within the past 2 years and not previously discussed in the journal club; the study must contain no major flaws of methodology; and the results of the study, if valid, must impact clinical practice in some way. Journal club will also discuss studies that may not impact clinical practice but advance current understanding of a particular field.


To download articles for Journal Club, please click the link in the right hand column. [Please note: some articles require subscription-based access through the Pitt or UPMC networks]

Adult CCM Journal Club Schedule

Datesort icon Fellow Faculty Title Article links
08-27-2012 Carlos Estrada, MD Ragi Murugan, MD Hydroxyethyl Starch 130/0.4 versus Ringer’s
09-10-2012 Akram Zaaqoq, MD Sachin Yende, MD Fever Contol Using External Cooling in Septic Shock
09-24-2012 Catie Carlson, MD David Huang, MD The Adult Respiratory Distress Syndrome Cognitive Outcomes Study
10-01-2012 Mohamed Khashan, MD Michael Pinsky, MD Intraaortic Balloon Support for Myocardial
10-08-2012 Esteban Mery, MD Jeremy Kahn, MD Intensive care unit bed availability and outcomes for hospitalized patients with sudden clinical deterioration
10-22-2012 Andre Holder, MD David Huang, MD Drotrecogin Alfa (Activated) in Adults with Septic Shock
10-29-2012 Shakeel Ahmed, MD Ragi Murugan, MD Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials
11-05-2012 Khursheed Haider, MD Michael Pinsky, MD Early Surgery versus Conventional Treatment
11-12-2012 Dennis Phillips Hernando Gomez Hydroxyethyl Starch or Saline for Fluid
11-26-2012 Tina Bermas Lou Alarcon Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol
12-03-2012 Jeremy Ward Matthew Rosengart Reversal of Immunoparalysis in Humans In Vivo A Double-Blind, Placebo-controlled, Randomized Pilot Study
12-10-2012 Chethan Puttarajappa Chenell Donadee Association Between a Chloride-Liberal vs Chloride-Restrictive Intravenous Fluid Administration Strategy and Kidney Injury
01-07-2013 Samer Melhem Murat Kaynar A Trial of Intracranial-Pressure Monitoringin Traumatic Brain Injury
01-28-2013 Sridhar Tirumala Hernando Gomez Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome
02-04-2013 Amy Liepert Jason Sperry The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study Comparative Effectiveness of a Time-Varying Treatment With Competing Risks
02-11-2013 Dena Noghrehkar Murat Kaynar Hypoglycemia and Risk of Death in Critically Ill Patients
03-04-2013 Manasi Singh, MD Murat Kaynar, MD Association Between Use of Lung-Protective Ventilation With Lower Tidal Volumes and Clinical Outcomes Among Patients Without Acute Respiratory Distress Syndrome A Meta-analysis
03-11-2013 Mai Vo Jeremy Kahn Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012
03-25-2013 Cheryl Six Sam Tisherman Effect of Not Monitoring Residual Gastric Volume on Risk of Ventilator-Associated Pneumonia in Adults Receiving Mechanical Ventilation and Early Enteral Feeding A Randomized Controlled Trial
04-22-2013 Mohammed Al-Jaghbeer Sachin Yende Transfusion Strategies for Acute Upper Gastrointestinal
04-29-2013 Kahoko Taki David Huang High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome
05-06-2013 Funmi Falade Michael Pinsky
09-18-2013 Jonathan Elmer Jeremy Kahn Implementation of an Evidence-based Extubation Readiness Bundle in 499 Brain-injured Patients. A Before–After Evaluation of a Quality Improvement Project
09-30-2013 Seema Tekwani Ragi Murugan Prone Positioning in Severe Acute Respiratory Distress Syndrome
10-07-2013 Namita Gupta Sachin Yende A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery
10-16-2013 Jaya Buddineni David Huang Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest A Randomized Clinical Trial
10-28-2013 Alea Lira Michael Pinsky Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock A Randomized Clinical Trial
11-04-2013 Frank Lodeserto Sachin Yende Acute Skeletal Muscle Wasting in Critical Illness
11-11-2013 Mary Przybysz Dennis Phillips Long-Term Cognitive Impairment after Critical Illness
11-20-2013 Justin Tawil Murat Kaynar Early Identification of Patients at Risk for Difficult Intubation in the Intensive Care Unit Development and Validation of the MACOCHA Score in a Multicenter Cohort Study
11-27-2013 Megan Rapp Matt Rosengart Effect of Early vs Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation The TracMan Randomized Trial
12-04-2013 Michelle Kincaid Jason Sperry Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock The CRISTAL Randomized Trial
01-29-2014 Ali Abdullah Mark Lischner Mechanical Chest Compressions and Simultaneous Defibrillation vs Conventional Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest The LINC Randomized Trial
02-17-2014 Daniel Haase Chenell Donadee Real-time ultrasound-guided subclavian vein cannulation versus the landmark method in critical care patients: A prospective randomized study
02-26-2014 Treb Becher Ivonne Daly Perceptions of Appropriateness of Care Among European and Israeli Intensive Care Unit Nurses and Physicians
03-03-2014 Angie Ingraham Sam Tisherman
03-12-2014 Jeff DellaVolpe David Huang
04-07-2014 Petros Kopterides Jeremy Kahn Histamine-2 Receptor Antagonists vs Proton Pump Inhibitors on Gastrointestinal Tract Hemorrhage and Infectious Complications in the Intensive Care Unit
04-16-2014 Prem Nattanmai Kees Polderman Real-time ultrasound-guided subclavian vein cannulation versus the landmark method in critical care patients: A prospective randomized study
04-28-2014 Matt Siedsma Sachin Yende
06-02-2014 Jorge Cabrera Michael Pinsky
07-30-2014 Jonathan Auerbach, MD Cameron Dezfulian, MD Mortality Related to Severe Sepsis and Septic Shock
08-13-2014 Michael Buscher, MD Lori Shutter, MD 1. Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury A Randomized Clinical Trial / 2. Family Presence During Brain Death Evaluation: A Randomized Controlled Trial
09-10-2014 Jaqui King, M.D. Peter Simon, M.D. Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism
10-29-2014 Ryotaro Kato, M.D. Michael Pinsky, M.D. High versus Low Blood-Pressure Target in Patients with Septic Shock
11-06-2014 Anes: Joshua King, MD; Courtney Garbee, MD: CCM: Sean DeChancie, MD Mark Lischner, MD Effect of Fenoldopam on Use of Renal Replacement Therapy Among Patients With Acute Kidney Injury After Cardiac Surgery A Randomized Clinical Trial
11-12-2014 Timothy Baptist, M.D. David Huang, M.D. Goal-Directed Resuscitation for Patients with Early Septic Shock
12-10-2014 Jeffrey Javed, M.D. Cameron Dezfulian, M.D. Trial of the Route of Early Nutritional Support in Critically Ill Adults
01-21-2015 Susan Cheng, M.D. Sachin Yende, M.D. Cost-effectiveness of Dalteparin vs Unfractionated Heparin for the Prevention of Venous Thromboembolism in Critically Ill Patients
02-11-2015 Joseph Shy,MD Hernando Gomez, MD Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery A Randomized Clinical Trial and Systematic Review
03-11-2015 Rupal Patel, MD Dr. Sherry Chou Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke
03-18-2015 Kate Tyson, MD & Chris Horvat, MD Ericka Fink & Holt Murray, MD 1. Short- and intermediate-term survival after extracorporeal membrane oxygenation in children with cardiac disease 2. An optimal transition time to extracorporeal cardiopulmonary resuscitation for predicting good neurological outcome in patients with out-of-hospital cardiac arrest: a propensity-matched study
04-08-2015 Matt Neal Matthew Rosengart, MD Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma The PROPPR Randomized Clinical Trial
04-29-2015 Eric Suess Dr. Ragi Murugan Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial
05-20-2015 Matt Kutcher, MD Joseph Darby, MD Effect of a Retrievable Inferior Vena Cava Filter Plus Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism A Randomized Clinical Trial
06-10-2015 Marcus Hoffman Jason Sperry, MD Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection
06-17-2015 Jake Jentzer, MD Lillian Emlet, MD High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure
07-08-2015 Oluwaseun Davies, MD Cameron Dezfulian, MD Prednisolone or Pentoxifylline for Alcoholic Hepatitis
07-29-2015 Florian Mayr, MD David Huang, MD Effect of High-Dose Vitamin D3 on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency The VITdAL-ICU Randomized Clinical Trial
08-12-2015 Munish Lapsia, MD Marie Baldisseri, MD Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults
08-19-2015 Sajid Kadir, MD Ali Al-Khafaji, MD Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function
09-09-2015 Jay Chellurri, MD Peter Simon, MD Systemic inflammatory response syndrome criteria in defining severe sepsis
09-30-2015 Daniel Glass, MD Scott Gunn, MD High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.
10-07-2015 Daniel Kievlan, MD Joseph Darby, MD Alignment of Do-Not-Resuscitate Status With Patients’ Likelihood of Favorable Neurological Survival After In-Hospital Cardiac Arrest
11-05-2015 Rachel Hadler, MD Murat Kaynar, MD Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation
11-11-2015 Sangeeth Dubbireddi, MD Jeremy Kahn, MD Intravascular Complications of Central Venous Catheterization by Insertion Site
12-09-2015 Jennifer Yu, MD Chenell Donadee, MD Liberal or Restrictive Transfusion after Cardiac Surgery
01-13-2016 Patrick Hackett, MD Hernando Gomez, MD Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the ICU
02-10-2016 Ed Yang, MD Dennis Phillips, DO Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
02-25-2016 Rajagopala Padmanabhan, MD Cameron Dezfulian, MD Hypothermia for Intracranial Hypertension after Traumatic Brain Injury
03-09-2016 Gina Howell, MD Matthew Rosengart, MD National Cluster-Randomized Trial of Duty-Hour Flexibility in Surgical Training
03-30-2016 Kusum Tom, MD Matthew Rosengart, MD High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial
04-13-2016 William Wallisch, MD Colleen Moran, MD and Sean DeChancie, MD Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery
04-21-2016 Torben Becker, MD Cameron Dezfulian, MD Vasopressin in Pediatric Vasodilatory Shock: A Multicenter Randomized Controlled Trial // Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock
05-11-2016 Anne Warner, MD Matthew Neal, MD Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium a randomized clinical trial.
06-08-2016 Juan Idrovo, MD Jason Sperry, MD Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery
06-29-2016 Joshua Keegan, MD Lori Shutter, MD Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage
07-06-2016 Hitesh Gidwani, MD Cameron Dezfullian, MD Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial)
07-13-2016 Debjit Saha, MD David Huang, MD Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit
08-10-2016 Abhishek Freyer, MD David Wallace, MD Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial
08-31-2016 Alexander Preus, MD Murat Kaynar, MD and William Wallisch, MD Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endotracheal Intubation in Patients With Acute Respiratory Distress Syndrome
09-14-2016 Pavan Thangudu, MD Scott Gunn, MD ICU Attending Handoff Practices: Results From a National Survey of Academic Intensivists
10-05-2016 Muhammad Tahseen, MD Cameron Dezfulian, MD Practice Patterns and Outcomes Associated With Use of Anticoagulation Among Patients With Atrial Fibrillation During Sepsis
11-09-2016 Rohan Panchamia, MD Hernando Gomez, MD Association Between Overnight Extubations and Outcomes in the Intensive Care Unit
11-30-2016 Melissa Loveranes, MD Matthew Rosengart, MD Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation on Reintubation and Postextubation Respiratory Failure in High-Risk Patients, A Randomized Clinical Trial
12-14-2016 Alexandra Briggs, MD Jason Sperry, MD Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery
01-11-2017 Yiyu Zhao, MD Dennis Phillips, MD Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery
02-08-2017 Fadi Tohme, MD David Huang, MD Video Laryngoscopy vs Direct Laryngoscopy on Successful First-Pass Orotracheal Intubation Among ICU Patients: A Randomized Clinical Trial
03-08-2017 Michael Klein, MD Matthew Rosengart, MD Ultrasound assessment of volume responsiveness in critically ill surgical patients: Two measurements are better than one
03-29-2017 Mary Assaad, MD David Huang, MD Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival
04-05-2017 Krystle Shafer, MD Jonathan Elmer, MD Prevalence and Localization of Pulmonary Embolism in Unexplained Acute Exacerbations of COPD: A Systematic Review and Meta-analysis
05-10-2017 Christopher Johnson, MD Hernando Gomez, MD Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study
05-31-2017 Benjamin Kautza, MD Matthew Neal, MD Every Minute Counts: Time to Delivery of Initial Massive Transfusion Cooler and Its Impact on Mortality
06-08-2017 Tim Kaselitz MD David Wallace MD and Cameron Dezfulian, MD Impact of 24/7 In-Hospital Intensivist Coverage on Outcomes in Pediatric Intensive Care
06-14-2017 Namir Khandker, MD Sherry Chou, MD Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial
07-05-2017 Vikram Balakumar, MD Ragi Murugan, MD Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis A Randomized Clinical Trial
08-09-2017 Aaron Skolnik, MD David Huang, MD Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke
08-16-2017 Nicholas Goodmanson, MD David Huang, MD Angiotensin II for the Treatment of Vasodilatory Shock
09-13-2017 Ruth Musselman, MD David Wallace, MD Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest
10-11-2017 Danish Malik, MD Jonathan Elmer, MD Hypothermia for Intracranial Hypertension after Traumatic Brain Injury

2011-2012 Adult CCM Journal Club Schedule