David T. Huang, MD, MPH, MACRO Director
Dr. Huang completed Emergency Medicine residency at Henry Ford Hospital in Detroit, followed by Critical Care Medicine (CCM) and a research NRSA fellowship at the University of Pittsburgh. He is Director of the Administrative and Long Term Follow Up Cores of the CRISMA Center within CCM, and Associate Director of the Abdominal Organ Transplant ICU, UPMC Montefiore. His research focuses on early management of infection and sepsis, neuromuscular blockade in ARDS, and conduct of clinical trials. He served as the Medical Monitor and Human Subjects Core Director of the ProCESS (Protocolized Care for Early Septic Shock) trial, and as of January 2017 is Principal Investigator of ProACT (Procalcitonin Antibiotic Consensus Trial) and a trial leader of the ROSE (Reevaluation Of Systemic Early neuromuscular blockade) trial.
Scott R. Gunn, MD, Co-Director (CCM)
He graduated from Brigham Young University with a BS (1987), and the University of Minnesota with an MD (1996). He completed residency training in Emergency Medicine at Hennepin County Medical Center in Minneapolis (1999) followed by fellowship training in Critical Care at the University of Pittsburgh (2001). He serves as medical director of UPMC’s Surgical Trauma ICU; medical director of UPMC’s Respiratory Therapy Department, and Chief of service, CCM Department. Dr. Gunn developed an interest in clinical research as an NRSA fellow. As a clinician, he has focused his research activities on supporting the research role of the department through facilitating clinical research. He has published eight peer-reviewed articles and ten abstracts. Dr. Gunn assumed responsibility for the Department’s Clinical Trials Program in 2004, and served as MACRO Director until mid-2010. He serves as a liaison with principal investigators within the department and provides study design and regulatory support for intra-department investigator initiated trials.
Barbara Early Young, BSN, RN, CCRC, CRC Director
Ms. Early Young is an accomplished clinical research coordinator, project and program manager with experience in the design, management and implementation of clinical investigations, both industry and federal. She is a member of the Association of Clinical Research Professionals, and past president of the Greater Pittsburgh Area Chapter. She has held a certification in Clinical Research Coordination for over 10 years. Her clinical background includes cardiology and oncology. She has managed the day to day operations of MACRO since 2005.
Jason L. Sperry, MD, MPH, Co-Director (Surgery)
Dr. Sperry is a Professor with a primary appointment in the Department of Surgery, Division of Trauma and General Surgery and secondary appointments in the Department of Critical Care Medicine and the Clinical and Translational Science Institute (CTSI) at the University of Pittsburgh. He is a physician trained in general surgery and surgical critical care with a masters’ degree in public health. Dr. Sperry's research focuses on the elucidation of the mechanisms that are responsible for sex-based outcome differences following injury, clinical outcomes following traumatic injury (primarily on massive transfusion), prehospital resuscitation, early correction of the coagulopathy that complicates injury, and the ability to predict a complicated post-injury course in the early prehospital and trauma bay setting. He is the principal investigator (PI) for the Linking Investigations Trauma and Emergency Services (LITES) network funded by the U.S. Department of Defense and PI of the PAMPer trial and STAAMP trials funded by the Prehospital Use of Plasma in Traumatic Hemorrhage (PUPTH) program and the Tranexamic Acid Clinical Research (TACR) program, under the direction of the Department of the Army. He is a co-investigator for the Trans-Agency Research Consortium for Trauma-Induced Coagulopathy (TACTIC) funded thru NHLBI, as well as multiple other NIH-funded grants. His overarching goal is to improve outcomes following traumatic injury.
Mazen S. Zenati, MD, MPH, PhD, Co-Director (Surgery)
Dr. Zenati is an Associate Professor of Clinical Research of Surgery, and Associate Professor of Epidemiology. Dr. Zenati's areas of clinical research include shock, hypothermia, splenic injury, trauma in the morbidly obese, injury prevention, trauma system, surgical oncology, robotic surgery, Infectious diseases, methodology of clinical research, medical education, and other related outcome clinical research.
Clifton W. Callaway, MD PhD, Co-Director (Emergency Medicine)
Dr. Callaway is Executive Vice Chair of Emergency Medicine and the Ronald D. Stewart Endowed Chair of Emergency Medicine Research. Dr. Callaway earned his MD in 1993, and his PhD in Neurosciences in 1992, both from the University of California in San Diego. He completed a residency in Emergency Medicine at the University of Pittsburgh in 1996, was Board Certified in Emergency Medicine in 1997 and again in 2007. Dr. Callaway has distinguished himself as an investigator and as a teacher of paramedics, medical students and physicians. He is recognized in the field of resuscitation medicine both locally and nationally. He developed a translational research program devoted to the topic of resuscitation from sudden death. A resident of the City of Pittsburgh for over 20 years, Dr. Callaway works at UPMC-Presbyterian Hospital in the emergency department. He has developed a clinical service line for post-cardiac arrest care, which works to improve and to ensure the best care for patients hospitalized after cardiac arrest as well as for their families. He coordinates his research in offices and laboratories at the University of Pittsburgh School of Medicine. He is the local PI for the Resuscitation Outcomes Consortium (ROC) and the Neurological Emergencies Treatment Trial (NETT) network.
Bryan McVerry, MD, Assistant Professor of Medicine, and Fellowship Director of the UPMC Medical Intensive Care Unit
Dr. McVerry received his B.S. in Mechanical Engineering from Lehigh University in 1992 followed by his M.D. from Georgetown University School of Medicine in 1997. Following internship in Internal Medicine and Pediatrics, he completed residency in Internal Medicine at the University of Chicago and then went on to study out of hospital cardiac arrest during a one-year research fellowship in the Emergency Resuscitation Research Center at the University of Chicago. He subsequently completed clinical and research fellowships in Pulmonary and Critical Care Medicine at Johns Hopkins University under the mentorship of Joe G.N. Garcia and Brett A. Simon. In August of 2005, Dr. McVerry joined the faculty of the Division of Pulmonary, Allergy, and Critical Care Medicine at the University of Pittsburgh as Assistant Professor. He currently serves as the Associate Director of the Medical ICU at UPMC Presbyterian Hospital, the Director of Translational Research for the Acute Lung Injury Center of Excellence, and the Associate Program Director for the Fellowship Training Program in Pulmonary and Critical Care Medicine.