In a beautiful piece of translational work by Kellum and others, the mechanisms whereby Remote Ischemic Preconditioning (RIPC) signals protection and its concentration by renal filtration is elaborated paving the way for a better informed phase 3 future clinical trial.
Zarbock A, et al. Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: A randomized clinical trial. JAMA. 2015