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TITRe2

http://www.nejm.org/doi/full/10.1056/NEJMoa1403612#t=articleTop

UK trial randomized 2007 adults undergoing nonemergent cardiac surgery to restrictive (7.5 g/dL) vs. liberal (9.0 g/dL) postoperative PRBC transfusion thresholds. Similar rates of combined primary endpoint, but significant increase in mortality in restrictive group and comparable between-group costs. Results are perhaps contrary to prevailing wisdom regarding transfusion targets.

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