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Anti-Xa Inhibitor Antidote

Rivoraxaban and Abixaban can result in substantial irreversible bleeding. In this NEJM article (http://www.nejm.org/doi/full/10.1056/NEJMoa1607887#t=article) Andexanet Alfa reversed major bleeing in ~80% of cases but resulted in thrombosis in 18%. Given the severity of the bleeds this still may be an important reversal agent.

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