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Wonshill Koh, MD

Fellow, Pediatric Cardiac Critical Care 
Clinical Instructor

412-692-7366


Education & Training

Degree

Year

Field

Texas A&M BS 2002 Biomedical Engineering
University of Missouri MD/PhD 2010 Medicine/Physiology
NSLIJ Cohen Children’s Hospital of New York Resident 2013 Pediatrics
Cleveland Clinic Children’s Hospital Fellow 2016 Pediatric Cardiology
Children's Hospital of Pittsburgh of UPMC Fellow Current Pediatric Cardiac Critical Care Medicine

 

Honors

Intern of the Month, April 2011, Cohen Children’s Medical Center, LIJ-NS Heath System, New Hyde Park, NY, 2011

Best graduate student poster award, Developmental Vascular Biology Workshop III, January 30-February 3, 2008, Pacific Grove, CA, 2008

Texas A&M University Undergraduate Research Fellow, 2002

 

Publications

 

Davis GE, Stratman AN, Sacharidou A, Koh W. Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting.” Int Rev Cell Mol Biol. 2011;288:101-65.

Sacharidou A, Koh W, Stratman AN, Mayo AM, Fisher KE, Davis GE. “Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events.” Blood 2010 June 24; 115(25): 5259-69.

Koh W, Sachidanandam K, Stratman AN, Sacharidou A, Mayo AM, Murphy EA, Cheresh DA, Davis GE. “Formation of endothelial lumens requires a coordinated PKC{epsilon}-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation.” J Cell Sci. 2009 Jun 1;122(Pt 11):1812-22.

Stratman AN, Saunders WB, Sacharidou A, Koh W, Fisher KE, Zawieja DC, Davis MJ, Davis GE. “Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3D collagen matrices.” Blood 2009;114(2):237-47.

Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, Mayo AH, Drakos SG, Marchuk DA, Davis GE, Li DY. “The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases.” Nat Med 2009 Feb;15(2):177-84. Epub 2009 Jan 18.

Koh W, Stratman AN, Sacharidou A, Davis GE. “In vitro three dimensional collagen matrix models of endothelial lumen formation during vasculogenesis and angiogenesis.” Methods Enzymol. 2008;443:83-101.

Koh W, Mahan RD, Davis GE. “Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.” J Cell Sci. 2008 Apr 1;121(Pt 7):989-1001. Epub 2008 Mar 4.

Davis GE, Koh W, Stratman AN. “Mechanisms controlling human endothelial lumen formation and tube assembly in three-dimensional extracellular matrices.” Birth Defects Res C Embryo Today. 2007 Dec;81(4):270-85. Review.

Fisher KE, Pop A, Koh W, Anthis NJ, Saunders WB, Davis GE. “Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling.” Mol Cancer. 2006 Dec 8;5:69.

Presentations

Lawerence V,  Gorski J, Koh W,  Bachrach B, “A 5q12.1 deletion disrupting the Phosphodiesterase 4D (PDE4D) gene presenting with persistent hyperinsulinism (HI) of infancy”, Pediatric Academic Societies Annual Meeting 2010, May 1-4, Vancouver, Canada. Poster presentation

Koh W, Sacharidou A, Fisher KE, Davis GE, “Regulation of endothelial lumen formation by Cdc42/alpha2beta1 integrin/membrane type-1 metalloproteinase complex in 3D collagen matrices”, Experimental Biology 2008, April 5-9, San Diego, CA. Oral presentation

Koh W, Mahan RD, Davis GE, “Cdc42/Rac1, their downstream effectors, and distinct Protein Kinase C isoforms regulate endothelial lumen formation in 3D collagen matrices”, Developmental Vascular Biology Workshop III, January 30-February 3, 2008, Pacific Grove, CA. Poster presentation

Koh W, Mareth AK, Sacharidou A, Fisher KE, Davis GE, “Coordinated regulation by Cdc42, integrin alpha2beta1, and membrane type-1 metalloproteinase-dependant signaling of capillary tube formation in 3D collagen matrices”,  Experimental Biology 2007, April 28- May 2, Washington DC. Oral presentation.

Koh W, Faske JB, Saunders WB, Davis GE, “Cdc42 and its downstream effectors control endothelial cell invasion and lumenal morphogenesis in 3D collagen matrices”, Experimental Biology 2006, April 1-4, San Francisco, CA. Oral presentation