Associate Professor, Critical Care Medicine and Clinical and Translational Sciences
Director, Clinical Epidemiology Program, CRISMA Center
I conduct epidemiologic and translational studies to understand how demographic factors and chronic health affects susceptibility to and outcomes of infection and severe sepsis. Using community-acquired pneumonia as a model of infection, I conduct epidemiologic research using population-based cohorts and large cohorts of patients hospitalized with infection. I also conduct translational research using biomarkers and genetic markers, and collaborate with basic scientists on animal models of sepsis to understand mechanisms.
1. Risk factors for susceptibility to pneumonia
Grants: K23AG025931, Yende - PI.
This project will examine the role of clinical risk factors, biomarkers, and genetic markers to develop novel risk prediction tools for pneumonia hospitalization. We also seek to understand the heterogeneity in the immune response to infection due to demographic factors (age, sex, and race) and chronic diseases. Sub-projects are:
2. Long-term consequences of septic shock
We have shown that survivors of pneumonia hospitalization have increased long-term mortality and the higher mortality cannot be solely explained by higher burden of chronic diseases prior to the occurrence of pneumonia. This project seeks to understand why survivors of infection have higher morbidity and mortality during recovery and underlying mechanisms. Sub-projects are:
Education & Training
|University of Mumbai, Seth G.S. Medical College, Mumbai, India||MB, BS||1995||Bachelor of Medicine & Bachelor of Surgery|
|Methodist Healthcare University Hospital, Memphis, TN||Residency||1998||Internal Medicine|
|Methodist Healthcare University Hospital, Memphis, TN||Research Associate||2002|
|University of Tennessee, Health Science Center, Memphis, TN||MS||2003||Epidemiology|
|University of Tennessee, Memphis, TN||Fellowship||2005||Pulmonary and Critical Care|
2003 Young Investigator Award (American College of Chest Physicians)
2000 Cecile Lehmann Mayer (American Collge of Chest Physicians)