Associate Professor, Surgery and Critical Care Medicine
Co-Director, Surgical Trauma Intensive Care Unit, UPMC Presbyterian
Matthew R. Rosengart, MD MPH received his undergraduate education at the Johns Hopkins University. He completed training in general surgery, an NIH fellowship in molecular biology, and a Master in Public Health at the University of Washington, whereafter he pursued a Trauma/Surgical Critical Care fellowship. He then joined the Departments of Surgery and Critical Care Medicine faculty at the University of Pittsburgh in 2004. Dr. Rosengart’s clinical practice has been devoted to care of the critically injured and critically ill ICU patient. His general surgery practice includes surgery for complex abdominal wall hernias, gallbladder disease, small and large bowel pathology, and complex pilonidal disease. His laboratory focuses upon the molecular biology of sepsis, hemorrhage, and traumatic injury in the contexts of organ injury, dysfunction, recovery and the aging process.
Dr. Rosengart’s lab has a long-standing record of examining the role of innate immunity in the systemic response to injury and infection, with particular expertise in calcium-dependent mechanisms and a translational perspective. His laboratory has focused upon the mechanisms involved in the response to injury in relevant sepsis and trauma models such as LPS-induced inflammation and organ dysfunction, cecal ligation and puncture (CLP) polymicrobial sepsis, warm hepatic ischemia/reperfusion (I/R) injury, and hemorrhagic shock. Extending these investigations, our laboratory he has defined the regulatory roles of calcium and CaMK transduction in the adaptive responses of autophagy, mitophagy, and mitochondrial biogenesis during sepsis-induced organ dysfunction and organ recovery. The translational perspective of his studies has provided mechanistic insight into the clinically relevant outcomes of organ dysfunction and survival. Recently his laboratory has focused on characterizing the immunomodulatory effects of light and its dimension (i.e. photoperiod, insolation, spectrum) on the host response to both septic and sterile insults. His clinical expertise is Injury Epidemiology with particular focuses in trauma system development and cognitive and decisional behavioral sciences in the context of compliance with evidence-based guidelines. He has additional on-going clinical-epidemiological studies in the areas of comparative effectiveness of processes of patient care, prolonged critical illness, sepsis, and multiple organ dysfunction.
Education & Training
|The Johns Hopkins University, Baltimore, MD||B.A.||1987-1991||Biology|
|University of Alabama at Birmingham, Birmingham, AL||M.D.||1991-1995||Medicine|
|University of Alabama at Birmingham, Birmingham, AL||Residency||1995-1998||General Surgery|
|University of Washington, Seattle, WA||Fellowship||1998-2000||Molecular Biology|
|University of Washington, Seattle, WA||Residency||2000-2002||General Surgery|
|University of Washington, Seattle, WA||MPH||2002-2003||Epidemiology|
|University of Washington, Seattle, WA||Fellowship||2002-2004||Trauma/Critical Care|
|2013-||University of Pittsburgh CTSI||Associate Professor with tenure|
|2011-||University of Pittsburgh Surgery||Associate Professor with tenure|
|2011-||University of Pittsburgh Critical Care Medicine||Associate Professor with tenure|
Ongoing Research Projects