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Jason L. Sperry, MD, MPH

Assistant Professor of Surgery and Critical Care

412.802.8270
Admin Assistant:
Joyce Selden
412.692.2850

I am an Assistant Professor with a primary appointment in the Department of Surgery, Division of Trauma and General Surgery and secondary appointments in the Department of Critical Care Medicine and the Clinical and Translational Science Institute at the University of Pittsburgh. I am a physician trained in general surgery and surgical critical care with a masters’ degree in public health. My research focuses on elucidation of the mechanisms that are responsible for sex based outcome differences following injury. The innate immune response following injury is a complex process whose intensity can be modulated at unique signaling points by different mediators with potential interaction. My work has helped demonstrate that, in addition to sex-hormone differences, alternative mechanisms including X-chromosome polymorphisms may alter the inflammatory response post-injury and may be responsible for differential outcomes across sex.
 

Education & Training

Degree

Year

Field

Case Western Reserve University, Cleveland, OH

BA

1989-1993

Chemistry/Psychology

Case Western Reserve School of Medicine, Cleveland, OH

MD

1993-1997

Medicine

The Johns Hopkins Hospital, Baltimore, MD

Residency

1997-2005

General Surgery

University of Texas at Houston School of Public Health

Masters of Public Health

2005-2006

Epidemiology, Biostatistics

University of Texas Southwestern Medical Center

Fellowship

2006-2007

Surgical Critical Care/ Trauma

 

 Academic Titles 

1997-1999, General Surgery Residency (PGY 1-2): The Johns Hopkins Hospital, Department of Surgery

1999-2001, Research Fellow (PGY 3-5): The Johns Hopkins Hospital,Department of Surgery                               

2002-2005, General Surgery Residency (PGY 6-8): The Johns Hopkins Hospital, Department of Surgery

2005-2006, Masters of Public Health (PGY 9): University of Texas at Houston School of Public Health and Assistant Instructor: University of Texas Southwestern Medical Center at Dallas, Department of Surgery, Division of Burn/Trauma/Critical care

2006-2007, Surgical Critical Care and Trauma Fellowship (PGY 10): University of Texas Southwestern Medical Center at Dallas, Department of Surgery, Division of Burn/Trauma/Critical care

2007-present, Assistant Professor of Surgery and Critical Care: Department of Surgery, Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh PA



Honors

 
Assistant Professor Clinical and Translational Science Institute Clinical Research Scholarship: 2 year NIH Career Development Award - KL2 RR024154-03
1999 National Research Service Award (NRSA) Grant, “Role of NF-kB in Vascular Transplant Grafts”,#HL 10250-01
1999 William J. von Liebig Foundation Research Fellowship Grant
2003 Zuidema Resident Research Award
2003 Baltimore Academy of Surgery Resident Research Award
  Alpha Omega Alpha Honor Society
1996, 1997 Figgie/Rawling Scholarship
1997 Association for Academic Surgery Student Research Award
  Phi Beta Kappa
  2-Time Academic All American, Divison III Collegiate Wrestling
  4-Time Scholar Athlete Award
1990 American Cancer Society Research Grant
1991 Joseph S. Silbur Research Fellowship
1992 Edward M. Chester Summer Research Scholarship

 

Current Research Projects

Characterization of the mechanisms responsible for sex based outcomes following injury
7/2010-6/2015
NIH NIGMS K23 GM093032
University of Pittsburgh
Mentored career development award looking at X chromosome genetic based mechanisms and sex hormone mediated mechanism that may be responsible for sex based outcome differences following injury

Role: Principal Investigator

Characterization of the effects of the early sex hormone environment on resuscitation requirements and coagulopathy following injury
8/2010-7/2011
National Trauma Institute / Department of Defense
University of Pittsburgh

Role: Principal Investigator

Inflammation and the Host Response to Injury Large Scale Collaborative Program
2007-current
NIH NIGMS U54 GM062119
University of Pittsburgh
Multi-center Prospective Cohort study looking at the genomic and proteomic response following hemorrhagic shock in severely injured patients at risk for multiple organ failure. 

Role: Site principle investigator
 

Completed Research Projects 

National Research Service Award (NRSA) Grant, “Role of NF-kB in Vascular Transplant Grafts”,  
#HL 10250-01, 1999 - 2000

Role: Mentored Research Fellow

NIH Clinical and Translational Science Award / NCRR
7/2008-6/2010
KL2 RR024154-03
University of Pittsburgh
University of Pittsburgh Multidisciplinary Clinical Research Scholars Program (CTSA KL2)

Mentored K12/KL2 research award focused on the characterization of the clinical mechanisms responsible for the gender dimorphism following injury.

Role: Principal Investigator
 

Publications

See Jason L. Sperry's Publications