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David T. Huang, MD, MPH, FACEP, FCCM

Associate Professor, Departments of Critical Care Medicine, Emergency Medicine, and Clinical and Translational Science

Director, Multidisciplinary Acute Care Research Organization (MACRO)

Administrative Core Director, CRISMA Center

Associate Medical Director, Transplant Intensive Care Unit, UPMC Montefiore

Admin Assistant: Meghan Buck
Dr. Huang trained in Emergency Medicine at Henry Ford Hospital, followed by a CCM Fellowship, NIH Research Fellowship, and MPH at the University of Pittsburgh. He is currently (Jan 2017) an Associate Professor of Critical Care Medicine, Emergency Medicine, and Clinical and Translational Science at the University of Pittsburgh. His research focuses on multicenter clinical trials that span the ED and ICU. He served as Medical Monitor of the ProCESS trial, and is currently PI of the ProACT trial (1R01GM101197;, and a leader of the ROSE trial (

Dr. Huang is a Fellow of the American College of Emergency Physicians and the American College of Critical Care Medicine. He is Director of MACRO (Multidisciplinary Acute Care Research Organization), Director of CRISMA Administrative Core, and Associate Director of the Abdominal Organ Transplant ICU.


See David T. Huang's Investigator page

Current Research Projects

ProACT – Procalcitonin Antibiotic Consensus Trial

ProCESS – Protocolized Care for Early Septic Shock

ROSE - Reevaluation Of Systemic Early neuromuscular blockade

Completed Research

The following refereed articles were generated primarily from completed research projects.

Huang DT, Osborn TM, Gunnerson KJ, Gunn SR, Trzeciak S, Kimball E, Fink MP, Angus DC, Dellinger RP, Rivers EP; Society of Critical Care Medicine; American College of Emergency Physicians; Society of Academic Emergency Medicine; Council of Emergency Medicine Residency Directors; Emergency Medicine Residents Association.  Critical care medicine training and certification for emergency physicians.  Crit Care Med. 2005;33:2104-2109. (PMID: 16148486)
Huang DT, Osborn T, Gunnerson K, Gunn S, Trzeciak S, Kimball E, Fink MP, Angus DC, Dellinger RP, Rivers EP.  Critical care medicine training and certification for emergency physicians.  Ann Emerg Med. 2005; 46:217-223. (PMID: 16126127)
Huang DT, Clermont G, Sexton JB, Karlo CA, Miller RG, Weissfeld LA, Rowan KM, Angus DC.  Perceptions of safety culture vary across the intensive care units of a single institution.  Crit Care Med. 2007;35:165-176. (PMID: 17110876)
Huang DT, Clermont G, Dremsizov TT, Angus DC.  Implementation of early goal-directed therapy for severe sepsis and septic shock: A decision analysis.  Crit Care Med. 2007;35:2090-2100. (PMID: 17855823)
Huang DT, Weissfeld LA, Kellum JA, Yealy DM, Kong L, Martino M, Angus DC; GenIMS Investigators.  Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia.  Ann Emerg Med. 2008;52:48-58.e2. (PMID: 18342993)
Huang DT, Angus DC, Kellum JA, Pugh NA, Weissfeld LA, Struck J, Delude RL, Rosengart MR, Yealy DM.  Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia.  CHEST. 2009;136:823-831. (PMID: 19363212)
Mayglothling JA, Gunnerson KJ, Huang DT.  Current practice, demographics and trends of critical care trained emergency physicians in the United States.  Acad Emerg Med. 2010;17:325-329. (PMID: 20370766)
Huang DT, Clermont G, Kong L, Weissfeld LA, Sexton JB, Rowan KM, Angus DC.  Intensive care unit safety culture and outcomes: a US multicenter study.  Int J Qual Health Care. 2010;22:151-161. (PMID: 20382662)
Al-Khafaji A, Huang DT.  Critical care management of patients with end-stage liver disease.  Crit Care Med. 2011 May;39(5):1157-1166 (PMID: 21336121)

Early BJ, Huang DT, Callaway CW, Zenati M, Angus DC, Gunn SR, Yealy DM, Unikel D, Billiar TR, Peitzman AB, Sperry JL. Multidisciplinary acute care research organization (MACRO): If you build it, they will come. J Trauma Acute Care Surg. 2013 Jul;75(1):106-9. (PMID: 23778448)
ProCESS/ARISE/ProMISe Methodology Writing Committee, Huang DT, Angus DC, Barnato A, Gunn SR, Kellum JA, Stapleton DK, Weissfeld LA, Yealy DM, Peake SL, Delaney A, Bellomo R, Cameron P, Higgins A, Holdgate A, Howe B, Webb SA, Williams P, Osborn TM, Mouncey PR, Harrison DA, Harvey SE, Rowan KM. Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe.  Intensive Care Med. 2013 Oct; 39(10): 1760-75. Epub 2013 Aug 30.  (PMID: 23958738)

ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. A randomized trial of protocol-based care for early septic shock. N Engl J. Med. 2014 May 1;370(18): 1683-93. Epub 2014 Mar 18.( PMID: 24635773)
Huang DT, Angus DC, Moss M, Thompson BT, Ferguson ND, Ginde A, Gong MN, Gundel S, Hayden DL, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Liu KD, Talmor DS, Yealy DM; ROSE Protocol Committee and the NIH NHLBI PETAL (Prevention and Early Treatment of Acute Lung injury) Network Investigators.. Design and Rationale of the Reevaluation of Systemic Early Neuromuscular Blockade (ROSE) Trial for Acute Respiratory Distress Syndrome. Ann Am Thorac Soc. 2016 Oct 25. [Epub ahead of print] PubMed PMID: 27779896.

PRISM Investigators.. Early, Goal-Directed Therapy for Septic Shock – A Patient-Level Meta-Analysis. N Engl J Med. 2017 Mar 21. doi: 10.1056/NEJMoa1701380. [Epub ahead of print] PubMed PMID: 28320242.