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Christopher W. Seymour, MD, MSc

Associate Professor, Departments of Critical Care and Emergency Medicine

Admin Assistant: Jackie Toboz

Dr. Seymour is Assistant Professor of Critical Care and Emergency Medicine at the University of Pittsburgh School of Medicine. He is core faculty member in the Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center in the Department of Critical Care, where he contributes to the Program on Critical Care Health Policy. He is affiliated faculty in the Center for Research on Emergency Medical Services (CREMS) in the Center for Emergency Medical Services of Western Pennsylvania. Dr. Seymour received his medical degree from the University of Pennsylvania before completing his internship and residency in Internal Medicine at the Hospital of the University of Pennsylvania. He then completed a fellowship in Pulmonary and Critical Care Medicine at the University of Washington, where he obtained masters degree in clinical epidemiology at the University of Washington, School of Public Health. Prior to joining the faculty at the University of Pittsburgh, he was instructor at the University of Washington.

Dr. Seymour’s research program focuses on emergency and critical care  - particularly the development of early diagnostic and prognostic models to advance treatments for those with acute illness. Specifically, he has developed a research program in pre-hospital sepsis and how care is continued in the emergency department. He was awarded the first National Institutes of Health grant on prehospital sepsis (NIGMS K23) and is now funded to explore sepsis endotypes during emergency care (NIGMS R35). He has received funding from the Society of Critical Care Medicine, American Heart Association, Surgical Infection Society and MedicOne Foundation. He spends his clinical time attending the Medical Intensive Care Unit at UPMC-Mercy Hospital.

Dr. Seymour lives in Pittsburgh with his family and three dogs. In his spare time, he enjoys amateur photography, cycling, and raising Dorset sheep on his farm.


Education & Training




Duke University, Durham, NC



Biology, Mathematics

University of Pennsylvania School of Medicine, Philadelphia, PA




University of Washington School of Public Health, Seattle, WA





Administrative Titles


 2011 – Present

 Critical Care Medicine

Core Faculty, Clinical Research, Investigation and Systems Modeling of Acute Illness (CRISMA) Center

 2011 - Present

 Emergency Medicine

Affliated Faculty, Center for Research on Emergency Medical Services



2016 Early Career Achievement Award, American Thoracic Society Critical Care Assembly


Global Rising Star in Intensive Care - Australia New Zealand Intensive Care Society


NIH Loan Repayment Award


Society of Critical Care Medicine Vision Grant 


American Thoracic Society, Critical Care Travel Award


Maurice Attie Senior Resident Teaching Award, Hospital of the University of Pennsylvania Internal Medicine Residency


 Konovsky Prize in Internal Medicine, University of Pennsylvania School of Medicine


 David Goodman Award in Clinical Research, University of Pennsylvania School of Medicine


Pinckus Prize for Achievement, University of Pennsylvania School of Medicine


Alpha Omega Alpha, Junior Inductee, University of Pennsylvania School of Medicine


Graduate, Magna Cum Laude, Duke University


Phi Beta Kappa, Duke University


Primary Research:



Supporting and Completed Research:


Think Sepsis App for EMS

Murine models of prehospital care

Tiered regionalization of critically ill patients during out-of-hospital care: an impact analysis

Out-of-hospital shock in non-injured patients: risk stratification and early resuscitation


See Dr. Seymour's Research Investigator Page



Recent publications:

Seymour CW, Kahn JM, Cooke CR, Watkins TR, Heckbert SR, Rea TD. Prediction of critical illness during out-of-hospital emergency care. JAMA. 2010; 304(7):747-754.  PMID: 20716737

Seymour CW, Kahn JM, Walkey A, Yealy DM, Rea TD, Angus DC.  Severe sepsis in prehospital emergency care: analysis of incidence, care, and outcomes. Am J Respir Crit Care Med. 2012 Dec 15;186 (12):1264-71. Epub 2012 Oct 18.  PMID: 23087028. PMCID: PMC3622444.

Seymour CW, Rosengart MR. Septic Shock: Advances in Diagnostic and Treatment. JAMA. 2015 Aug 18; 314(7):708-17. Review. Erratum in: JAMA. 2015 Oct 6: 314(13):1404. PMID: 26284722. PMCID: PMC4646706

Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst F, Rea TD, Scherag A, Rubenfeld GD, Kahn JM, Shankar-Hari M, Singer M, Deutschmann CS, Escobar GJ, Angus DC. Assessment of clinical criteria for sepsis. JAMA. 2016 Feb 23; 315(8): 762-74. PMID 26903335

See more of Christopher Seymour's Publications