"Evaluation of a multi-parameter flow cytometry assay for molecular diagnosis of innate and adaptive immune depression in pediatric severe septic patients"
Dr. Podd researches immune cell function in pediatric sepsis. Severe sepsis in children has a number of subtypes, of which decreased immune function, or immune depression, is associated with significant morbidity and mortality. Podd’s work aims to identify which molecular pathways are altered in patients with immune depression in order to deliver personalized medicine as new biologic therapies emerge.
"Barriers, Facilitators and Current Practices Related to the Conduct of Timely Interdisciplinary Family Meetings in the ICU"
Dr. Seaman researches interdisciplinary family meetings in the ICU and why this beneficial practice is not routinely carried out in a timely manner in many ICUs. In a previous study, she and her fellow researchers conducted qualitative phone interviews with ICU clinicians from diverse geographic and clinical settings to better understand what factors may hinder or help the conduct of timely family meetings. Participants described multiple barriers and facilitators occurring at all levels, including clinician, unit, and hospital. The Innovation Grant will enable Seaman to validate these findings in a national sample of ICU medical directors and nurse managers, in order to develop a scalable intervention to ensure timely interdisciplinary family meetings in the ICU.